SNAP-7941 is a drug used in scientific research, which is a selective, non-peptide antagonist at the

melanin concentrating hormone Melanin-concentrating hormone (MCH), also known as pro-melanin stimulating hormone (PMCH), is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation ...

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

MCH₁. In initial animal studies it had promising

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

, antidepressant and

anorectic An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic. The term is (from the Greek ''ἀν-'' (an-) = "without" a ...

effects, but subsequent trial results were disappointing, and the main significance of SNAP-7941 is as the

lead compound A lead compound (, i.e. a "leading" compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacology, pharmacological or biological activity likely to be therapeutical ...

from which more potent and selective antagonists such as SNAP-94847 were developed, although it continues to be used for research into the function of the MCH₁ receptor.

References

Experimental antidepressants Anxiolytics Ethers Fluoroarenes Anilides Pyrimidones Methyl esters {{Pharma-stub