SIB-1893 is a drug used in scientific research which was one of the first compounds developed that acts as a selective
antagonist for the
metabotropic glutamate receptor
The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. Like all glutamate re ...
subtype
mGluR5.
It has
anticonvulsant and
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...
effects,
and reduces glutamate release.
It has also been found to act as a positive allosteric modulator of
mGluR4.
References
Pyridines
MGlu5 receptor antagonists
Vinylbenzenes
{{anticonvulsant-stub