SIB-1757 is a drug used in scientific research which was one of the first compounds developed that acts as a selective antagonist for the

metabotropic glutamate receptor The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs. Like all glutamate re ...

subtype mGluR₅. It has anti-

hyperalgesia Hyperalgesia ( or ; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can ...

effects in animals. SIB-1757 along with other mGluR₅ antagonists has been shown to have neuroprotective and hepatoprotective effects, and it is also used to study the role of the mGluR₅ receptor in brain development.

References

Pyridines Azo compounds MGlu5 receptor antagonists {{nervous-system-drug-stub