SB-649,915 is a

serotonin reuptake inhibitor A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT). This in turn leads to incre ...

and 5-HT_1A and 5-HT_1B receptor antagonist which is being investigated for its antidepressant effects. Relative to the

selective serotonin reuptake inhibitor Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellul ...

s (SSRIs), SB-649,915 has a faster

onset of action Onset of action is the duration of time it takes for a drug's effects to come to prominence upon administration. With oral administration, it typically ranges anywhere from 20 minutes to over an hour, depending on the drug in question. Other meth ...

and may also have greater clinical efficacy as well. This can be attributed to blockade of 5-HT_1A and 5-HT_1B

autoreceptor An autoreceptor is a type of receptor located in the membranes of nerve cells. It serves as part of a negative feedback loop in signal transduction. It is only sensitive to the neurotransmitters or hormones released by the neuron on which the au ...

s which inhibit serotonin release.

References

{{Serotonin receptor modulators 5-HT1 antagonists Benzoxazines Piperidines Quinolines Selective serotonin reuptake inhibitors Lactams Phenol ethers

See also

References