SB-258719 is a drug developed by GlaxoSmithKline which acts as a selective 5-HT₇

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

partial inverse agonist, and was the first such ligand identified for 5-HT₇. Its use in research has mainly been in demonstrating the potential use for 5-HT₇ agonists as potential novel analgesics, due to the ability of SB-258719 to block the analgesic effects of a variety of 5-HT₇ agonists across several different testing models.

References

5-HT7 antagonists Piperidines Sulfonamides {{nervous-system-drug-stub