SB-206553 is a drug which acts as a mixed antagonist for the 5-HT_2B and 5-HT_2C serotonin

receptor Receptor may refer to: * Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...

s. It has

anxiolytic An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...

properties in animal studies and interacts with a range of other drugs. It has also been shown to act as a

positive allosteric modulator In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...

of α₇

nicotinic acetylcholine receptor Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral ner ...

s. Modified derivatives of SB-206553 have been used to probe the structure of the 5-HT_2B receptor.

References

5-HT2 antagonists Nicotinic agonists Ureas Tertiary amines Indoles 3-Pyridyl compounds {{nervous-system-drug-stub