Royal jelly is a

honey bee A honey bee (also spelled honeybee) is a eusocial flying insect within the genus ''Apis'' of the bee clade, all native to Afro-Eurasia. After bees spread naturally throughout Africa and Eurasia, humans became responsible for the current cosm ...

secretion that is used in the nutrition of

larva A larva (; plural larvae ) is a distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle. ...

e and adult

queens Queens is a borough of New York City, coextensive with Queens County, in the U.S. state of New York. Located on Long Island, it is the largest New York City borough by area. It is bordered by the borough of Brooklyn at the western tip of Long ...

. It is secreted from the

gland In animals, a gland is a group of cells in an animal's body that synthesizes substances (such as hormones) for release into the bloodstream (endocrine gland) or into cavities inside the body or its outer surface (exocrine gland). Structure De ...

s in the

hypopharynx The pharynx (plural: pharynges) is the part of the throat behind the mouth and nasal cavity, and above the oesophagus and trachea (the tubes going down to the stomach and the lungs). It is found in vertebrates and invertebrates, though its struct ...

of nurse bees, and fed to all larvae in the colony, regardless of sex or caste.Graham, J. (ed.) (1992) ''The Hive and the Honey Bee'' (Revised Edition). Dadant & Sons. Larvae in royal jelly

During the process of creating new queens, the workers construct special queen cells. The larvae in these cells are fed with copious amounts of royal jelly. This type of feeding triggers the development of queen morphology, including the fully developed

ovaries The ovary is an organ in the female reproductive system that produces an ovum. When released, this travels down the fallopian tube into the uterus, where it may become fertilized by a sperm. There is an ovary () found on each side of the body. T ...

needed to lay eggs. Royal jelly is sometimes used in

alternative medicine Alternative medicine is any practice that aims to achieve the healing effects of medicine despite lacking biological plausibility, testability, repeatability, or evidence from clinical trials. Complementary medicine (CM), complementary and al ...

under the category apitherapy. It is often sold as a

dietary supplement A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources or that are synthetic in order ...

for humans, but the

European Food Safety Authority The European Food Safety Authority (EFSA) is the agency of the European Union (EU) that provides independent scientific advice and communicates on existing and emerging risks associated with the food chain. EFSA was established in February 2002, ...

has concluded that current evidence does not support the claim that consuming royal jelly offers health benefits to humans. In the United States, the

Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

has taken legal action against companies that have marketed royal jelly products using unfounded claims of health benefits.

Production

Royal jelly is secreted from the glands in the heads of worker bees and is fed to all bee larvae, whether they are destined to become drones (males), workers (sterile females), or queens (fertile females). After three days, the drone and worker larvae are no longer fed with royal jelly, but queen larvae continue to be fed this special substance throughout their development.

Composition

Royal jelly is 67% water, 12.5%

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

, 11% simple

sugar Sugar is the generic name for sweet-tasting, soluble carbohydrates, many of which are used in food. Simple sugars, also called monosaccharides, include glucose, fructose, and galactose. Compound sugars, also called disaccharides or do ...

s (

monosaccharide Monosaccharides (from Greek '' monos'': single, '' sacchar'': sugar), also called simple sugars, are the simplest forms of sugar and the most basic units (monomers) from which all carbohydrates are built. They are usually colorless, water- so ...

s), 6%

fatty acid In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, f ...

s and 3.5% 10-hydroxy-2-decenoic acid (10-HDA). It also contains trace

minerals In geology and mineralogy, a mineral or mineral species is, broadly speaking, a solid chemical compound with a fairly well-defined chemical composition and a specific crystal structure that occurs naturally in pure form.John P. Rafferty, ed ...

, antibacterial and antibiotic components,

pantothenic acid Pantothenic acid, also called vitamin B5 is a water-soluble B vitamin and therefore an essential nutrient. All animals require pantothenic acid in order to synthesize coenzyme A (CoA) – essential for fatty acid metabolism – as well as to, ...

(vitamin B5), pyridoxine (

vitamin B6 Vitamin B6 is one of the B vitamins, and thus an essential nutrient. The term refers to a group of six chemically similar compounds, i.e., " vitamers", which can be interconverted in biological systems. Its active form, pyridoxal 5′-phosp ...

) and trace amounts of

vitamin C Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits and vegetables, also sold as a dietary supplement and as a topical 'serum' ingredient to treat melasma (dark pigment spots) ...

, but none of the fat-soluble vitamins: A, D, E or K.

Proteins

Major royal jelly proteins (MRJPs) are a family of proteins secreted by honey bees. The family consists of nine proteins, of which MRJP1 (also called royalactin), MRJP2, MRJP3, MRJP4, and MRJP5 are present in the royal jelly secreted by worker bees. MRJP1 is the most abundant, and largest in size. The five proteins constitute 83–90% of the total proteins in royal jelly. Royal jelly has been used in

traditional medicine Traditional medicine (also known as indigenous medicine or folk medicine) comprises medical aspects of traditional knowledge that developed over generations within the folk beliefs of various societies, including indigenous peoples, before the ...

since ancient times, and the MRJPs are shown to be the main medicinal components. They are synthesised by a family of nine genes (''mrjp'' genes), which are in turn members of the ''yellow'' family of genes such as in the fruitfly (''

Drosophila ''Drosophila'' () is a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many speci ...

'') and bacteria. They are attributed to be involved in differential development of queen larva and worker larvae, thus establishing division of labour in the bee colony.

Epigenetic effects

The honey bee queens and workers represent one of the most striking examples of environmentally controlled

phenotypic In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological pr ...

polymorphism. Even if two larvae had identical DNA, one raised to be a worker, the other a queen, the two adults would be strongly differentiated across a wide range of characteristics including anatomical and physiological differences, longevity, and reproductive capacity. Queens constitute the female sexual caste and have large active ovaries, whereas female workers have only rudimentary, inactive ovaries and are functionally sterile. The queen–worker developmental divide is controlled

epigenetically In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are "o ...

by differential feeding with royal jelly; this appears to be due specifically to the protein royalactin. A female larva destined to become a queen is fed large quantities of royal jelly; this triggers a cascade of molecular events resulting in development of a queen. It has been shown that this phenomenon is mediated by an epigenetic modification of DNA known as CpG methylation. Silencing the expression of an enzyme that methylates DNA in newly hatched larvae led to a royal jelly-like effect on the larval developmental trajectory; the majority of individuals with reduced DNA methylation levels emerged as queens with fully developed ovaries. This finding suggests that

DNA methylation DNA methylation is a biological process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts ...

in honey bees allows the expression of epigenetic information to be differentially altered by nutritional input.

Use by humans

Cultivation

Royal jelly is harvested by stimulating colonies with movable frame hives to produce queen bees. Royal jelly is collected from each individual queen cell (

honeycomb A honeycomb is a mass of hexagonal prismatic wax cells built by honey bees in their nests to contain their larvae and stores of honey and pollen. Beekeepers may remove the entire honeycomb to harvest honey. Honey bees consume about of honey ...

) when the queen larvae are about four days old. These are the only cells in which large amounts are deposited; when royal jelly is fed to worker larvae, it is fed directly to them, and they consume it as it is produced, while the cells of queen larvae are "stocked" with royal jelly much faster than the larvae can consume it. Therefore, only in queen cells is the harvest of royal jelly practical. A well-managed hive during a season of 5–6 months can produce approximately of royal jelly. Since the product is perishable, producers must have immediate access to proper cold storage (e.g., a household refrigerator or freezer) in which the royal jelly is stored until it is sold or conveyed to a collection center. Sometimes

honey Honey is a sweet and viscous substance made by several bees, the best-known of which are honey bees. Honey is made and stored to nourish bee colonies. Bees produce honey by gathering and then refining the sugary secretions of plants (primar ...

beeswax Beeswax (''cera alba'') is a natural wax produced by honey bees of the genus ''Apis''. The wax is formed into scales by eight wax-producing glands in the abdominal segments of worker bees, which discard it in or at the hive. The hive work ...

is added to the royal jelly, which is thought to aid its preservation.

Adverse effects

Royal jelly may cause allergic reactions in humans, ranging from

hives Hives, also known as urticaria, is a kind of skin rash with red, raised, itchy bumps. Hives may burn or sting. The patches of rash may appear on different body parts, with variable duration from minutes to days, and does not leave any long-last ...

asthma Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, co ...

, to even fatal

anaphylaxis Anaphylaxis is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of use of emergency medication on site. It typically causes more than one of the follo ...

. The incidence of allergic side effects in people who consume royal jelly is unknown. The risk of having an allergy to royal jelly is higher in people who have other allergies.

Notes

References

* * * * * Braines, L.N. (1959). Royal jelly I. Inform. Bull. Inst. Pchelovodstva, 31 pp (with various articles) * Braines, L.N. (1960). Royal jelly II. Inform. Bull. Inst. Pchelovodstva, 40 pp. * Braines, L.N. (1962). Royal jelly III. Inform. Bull. Inst. Pchelovodstva, 40 * Chauvin, R. and Louveaux, 1. (1956) Etdue macroscopique et microscopique de lagelee royale. L'apiculteur. * * De Belfever, B. (1958) La gelee royale des abeilles. Maloine, Paris. * Destrem, H. (1956) Experimentation de la gelee royale d'abeille en pratique geriatrique (134 cas). Rev. Franc. Geront, 3. * * Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. oyal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro.] ''Biomed Res.'' 2007 Oct;28(5):261-6. * * Inoue, T. (1986). The use and utilization of royal jelly and the evaluation of the medical efficacy of royal jelly in Japan. Proceeding sof the XXXth International Congress of Apiculture, Nagoya, 1985, Apimondia, 444-447 * * * * * Kucharski R, Maleszka, J, Foret, S, Maleszka, R, Nutritional Control of Reproductive Status in Honeybees via DNA Methylation. Science. 2008 Mar 28;319(5871):1827-3 * * * * * * Nakamura, T. (1986) Quality standards of royal jelly for medical use. proceedings of the XXXth International Congress of Apiculture, Nagoya, 1985

Apimondia Apimondia or International Federation of Beekeepers' Associations promotes scientific, ecological, social and economic apicultural development in all countries and the cooperation of beekeepers` associations, scientific bodies and of individual ...

(1986) 462–464. * * * Takenaka, T. Nitrogen components and carboxylic acids of royal jelly. In Chemistry and biology of social insects (edited by Eder, J., Rembold, H.). Munich, German Federal Republic, Verlag J. Papemy (1987): 162–163. * * Winston, M, The Biology of the Honey Bee, 1987, Harvard University Press

External links

* {{DEFAULTSORT:Royal Jelly Bee products Dietary supplements Beekeeping Animal glandular products