Riligustilide is a
nonsteroidal A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative. Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.
List of nonsteroidal steroid receptor mo ...
phytoprogestogen that is found in ''
Ligusticum chuanxiong''.
It is a very weak
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ag ...
of the
progesterone receptor
The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.
In humans, PR is encoded by a single ''PGR'' gene resid ...
(EC
50 ≈ 81 μM).
Another compound in the plant,
3,8-dihydrodiligustilide, is also a phytoprogestogen, but is almost 1,000-fold more
potent in comparison (
EC50 = 90 nM).
See also
*
Kaempferol
Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. Kaempferol is a yellow crystalline solid with a meltin ...
*
Tanaproget
References
Progestogens
Cyclobutanes
Lactones
Alkene derivatives
Spiro compounds
{{genito-urinary-drug-stub