Reticulate acropigmentation of Kitamura is a type of
pigmentation disorder of the
skin
Skin is the layer of usually soft, flexible outer tissue covering the body of a vertebrate animal, with three main functions: protection, regulation, and sensation.
Other animal coverings, such as the arthropod exoskeleton, have different de ...
.
It presents with
coloured freckle-like and slightly depressed
flat spots arranged in a lace-like pattern on the backs of hands and feet.
[ It tends to occur in skin folds of teenagers and in early adulthood, and darkens over time.][
It is inherited in an autosomal-dominant fashion.][
The condition is rare.][
]
Genetics
This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10
A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ''ADAM10'' gene.
Function
Members of the ADAM family are cell surface proteins with a un ...
) gene. This association was first shown in 2013.
See also
* Skin lesion
A skin condition, also known as cutaneous condition, is any medical condition that affects the integumentary system—the organ system that encloses the body and includes skin, nails, and related muscle and glands. The major function of th ...
* List of cutaneous conditions
References
External links
Disturbances of human pigmentation
{{Cutaneous-condition-stub