Regina Kapeller-Adler, born Regina Kapeller, (28 June 1900 – 31 July 1991) was an Austrian biochemist who, in 1934, devised an innovative test for early pregnancy based on the detection of

histidine Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated –NH3+ form under biological conditions), a carboxylic acid group (which is in the d ...

in urine. As a Jew, she was forced to leave Austria following the country's annexation into

Nazi Germany Nazi Germany (lit. "National Socialist State"), ' (lit. "Nazi State") for short; also ' (lit. "National Socialist Germany") (officially known as the German Reich from 1933 until 1943, and the Greater German Reich from 1943 to 1945) was ...

in the

Anschluss The (, or , ), also known as the (, en, Annexation of Austria), was the annexation of the Federal State of Austria into the German Reich on 13 March 1938. The idea of an (a united Austria and Germany that would form a " Greater Germany ...

and went to work with the noted geneticist

Francis Crew Francis Albert Eley Crew FRS FRSE LLD (2 March 1886 – 26 May 1973) was an English animal geneticist. He was a pioneer in his field leading to the University of Edinburgh’s place as a world leader in the science of animal genetics. He was t ...

at the Institute of Animal Genetics at the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...

. She worked at the Edinburgh Royal Infirmary during the Second World War and subsequently joined the pharmacology department of the University of Edinburgh and worked as a lecturer in chemistry. Towards the end of her career, she worked in obstetrics and gynaecology. In 1973, she received the Golden Honorary Diploma, an honorary degree of the University of Vienna, which was presented to her by Austrian biochemist

Hans Tuppy Hans Tuppy (born July 22, 1924) is an Austrian biochemist who participated in the sequencing of insulin, and became Austria's first university professor for biochemistry. He was Austrian Minister for Science and Research from 1987 to 1989. Fami ...

Early life

Regina Kapeller was born on 28 June 1900 in Stanislau (now Ivano-Frankivsk), Galicia,

Austria-Hungary Austria-Hungary, often referred to as the Austro-Hungarian Empire,, the Dual Monarchy, or Austria, was a constitutional monarchy and great power in Central Europe between 1867 and 1918. It was formed with the Austro-Hungarian Compromise of ...

. Her father, Moritz Kapeller, was employed by the

Canadian Pacific The Canadian Pacific Railway (french: Chemin de fer Canadien Pacifique) , also known simply as CPR or Canadian Pacific and formerly as CP Rail (1968–1996), is a Canadian Class I railway incorporated in 1881. The railway is owned by Canadi ...

and Royal Mail Lines. Her early education was at a school in

Brody Brody ( uk, Броди; russian: Броды, Brodï; pl, Brody; german: Brody; yi, בראָד, Brod) is a city in Zolochiv Raion of Lviv Oblast (province) of western Ukraine. It is located in the valley of the upper Styr River, approximately ...

Lviv Lviv ( uk, Львів) is the largest city in western Ukraine, and the seventh-largest in Ukraine, with a population of . It serves as the administrative centre of Lviv Oblast and Lviv Raion, and is one of the main cultural centres of Ukrain ...

. In 1928, Regina Kapeller married Dr Ernst Adler (1899–1970) and they had a daughter, Liselotte Adler (later Mrs Kastner) in 1934.

Career

Kapeller-Adler obtained her doctorate in chemistry from the

University of Vienna The University of Vienna (german: Universität Wien) is a public research university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world. With its long and rich hist ...

in 1923 and became a demonstrator at the Institute for Medical Chemistry of the University of Vienna in 1926. She was discouraged from pursuing a habilitation because she was a woman and Jewish, and worked unpaid. In 1934, she developed an innovative chemical test for early pregnancy using the detection of

excretion in urine that gained her international recognition. Kapeller-Adler began to study for a medical degree at the University of Vienna in 1934 while working part-time at the Biochemical Laboratory of the Health Insurance Fund from 1935 to 1936. Between 1936 and 1937, she was head of the Laboratory for Clinical and Medical-Chemical Diagnostics of the Sanatoriums Hera in Vienna. After the

in 1938, during which

annexed Austria, Kapeller-Adler and her husband lost their jobs due to being Jewish, and were unable to complete their studies at the university. In 1939, she moved to

Edinburgh Edinburgh ( ; gd, Dùn Èideann ) is the capital city of Scotland and one of its 32 council areas. Historically part of the county of Midlothian (interchangeably Edinburghshire before 1921), it is located in Lothian on the southern shore of t ...

, Scotland, on the invitation of the English geneticist

to work at the Institute of Animal Genetics at the

, then the only pregnancy diagnosis centre in the United Kingdom. Her husband travelled with her and was briefly interned as an "enemy alien" before being released and starting a medical practice in Edinburgh in 1943. Kapeller-Adler was awarded the degree of

Doctor of Science Doctor of Science ( la, links=no, Scientiae Doctor), usually abbreviated Sc.D., D.Sc., S.D., or D.S., is an academic research degree awarded in a number of countries throughout the world. In some countries, "Doctor of Science" is the degree used f ...

by the University of Edinburgh in 1941. She worked at the

Edinburgh Royal Infirmary The Royal Infirmary of Edinburgh, or RIE, often (but incorrectly) known as the Edinburgh Royal Infirmary, or ERI, was established in 1729 and is the oldest voluntary hospital in Scotland. The new buildings of 1879 were claimed to be the largest v ...

from 1940 to 1944. Subsequently, she joined the pharmacology department of the University of Edinburgh and worked as a lecturer in chemistry from 1951 to 1964. Starting in 1968, she worked locally in obstetrics and gynaecology. In 1973 she received the Golden Honorary Diploma, an

honorary degree An honorary degree is an academic degree for which a university (or other degree-awarding institution) has waived all of the usual requirements. It is also known by the Latin phrases ''honoris causa'' ("for the sake of the honour") or ''ad hon ...

from the University of Vienna, presented to her by Austrian biochemist

Death and legacy

Kapeller-Adler died in Edinburgh on 31 July 1991 at the age of 91.

Selected publications

"Urinary Histidine in the Diagnosis of Pregnancy"
''

JAMA ''The Journal of the American Medical Association'' (''JAMA'') is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of biom ...

'', 27 June 1936, , pp. 2240–2241. *''Amine Oxidases and Methods for their Study''. Wiley-Interscience, New York & London, 1970.

References

External links

* {{DEFAULTSORT:Kapeller-Adler, Regina 1900 births 1991 deaths Women biochemists Academics of the University of Edinburgh Austrian biochemists Austrian women academics University of Vienna alumni Jewish women scientists Austrian emigrants to Scotland Jewish emigrants from Austria after the Anschluss to the United Kingdom Physicians of the Royal Infirmary of Edinburgh