Propanidid is an ultra short-acting
phenylacetate general anesthetic
General anaesthetics (or anesthetics, see spelling differences) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. Clinical definitions are also extended to include an induced coma ...
. It was originally introduced by
Bayer in 1963 but
anaphylactic reaction
Anaphylaxis is a serious, potentially fatal allergic reaction and medical emergency that is rapid in onset and requires immediate medical attention regardless of use of emergency medication on site. It typically causes more than one of the follo ...
s caused it to be withdrawn shortly afterwards.
Even though
Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether propanidid itself may have contributed to the reactions.
It has been argued that the toxic effects or reactions to propanidid (and
Althesin) were due to the drugs themselves.
Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer, suggesting that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.
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{{GABAAR PAMs
General anesthetics
Acetate esters
Phenol ethers
Carboxamides
GABAA receptor positive allosteric modulators