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Polysorbates are a class of
NIH PEG-60 (Polysorbate 60)
Household Products Database {{organic-chemistry-stub Non-ionic surfactants Food additives Colloidal chemistry E-number additives
Polysorbates are a class of emulsifier
An emulsion is a mixture of two or more liquids that are normally immiscible (unmixable or unblendable) owing to liquid-liquid phase separation. Emulsions are part of a more general class of two-phase systems of matter called colloids. Althoug ...
s used in some pharmaceuticals and food preparation. They are commonly used in oral and topical pharmaceutical dosage forms. They are also often used in cosmetics to solubilize essential oil
An essential oil is a concentrated hydrophobic liquid containing volatile (easily evaporated at normal temperatures) chemical compounds from plants. Essential oils are also known as volatile oils, ethereal oils, aetheroleum, or simply as the o ...
s into water-based products. Polysorbates are oily liquids derived from ethoxylated sorbitan (a derivative of sorbitol
Sorbitol (), less commonly known as glucitol (), is a sugar alcohol with a sweet taste which the human body metabolizes slowly. It can be obtained by reduction of glucose, which changes the converted aldehyde group (−CHO) to a primary alcoho ...
) ester
In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides ...
ified with fatty acid
In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, f ...
s. Common brand names for polysorbates include Kolliphor, Scattics, Alkest, Canarcel, and Tween.Hubert Schiweck, Albert Bär, Roland Vogel, Eugen Schwarz, Markwart Kunz, Cécile Dusautois, Alexandre Clement, Caterine Lefranc, Bernd Lüssem, Matthias Moser, Siegfried Peters "Sugar Alcohols" Ullmann's Encyclopedia of Industrial Chemistry, 2012, Wiley-VCH, Weinheim.
Examples
* Polysorbate 20 (polyoxyethylene (20) sorbitan monolaurate) * Polysorbate 40 (polyoxyethylene (20) sorbitan monopalmitate) * Polysorbate 60 (polyoxyethylene (20) sorbitan monostearate) *Polysorbate 80
Polysorbate 80 is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics. This synthetic compound is a viscous, water-soluble yellow liquid.
Chemistry
Polysorbate 80 is derived from polyethoxylated sorbitan and ...
(polyoxyethylene (20) sorbitan monooleate)
The number following the 'polysorbate' part is related to the type of major fatty acid associated with the molecule. Monolaurate is indicated by 20, monopalmitate is indicated by 40, monostearate by 60, and monooleate by 80. The number 20 following the 'polyoxyethylene' part refers to the total number of oxyethylene (–CH2CH2O–) groups found in the molecule.
See also
*Sorbitan monolaurate
Sorbitan monolaurate is a mixture of esters formed from the fatty acid lauric acid and polyols derived from sorbitol, including sorbitan and isosorbide. As a food additive, it is designated with the E number E493.
See also
* Sorbitan monostearat ...
* Sorbitan monostearate
Sorbitan monostearate is an ester of sorbitan (a sorbitol derivative) and stearic acid and is sometimes referred to as a synthetic wax.
* Sorbitan tristearate
Sorbitan tristearate is a nonionic surfactant. It is variously used as a dispersing agent, emulsifier, and stabilizer, in food and in aerosol sprays. As a food additive, it has the E number
E numbers ("E" stands for "Europe") are codes fo ...
* Sorbitan monooleate
References
External links
NIH PEG-60 (Polysorbate 60)
Household Products Database {{organic-chemistry-stub Non-ionic surfactants Food additives Colloidal chemistry E-number additives