Poly ICLC is an
immunostimulant. It is
polyinosinic-polycytidylic acid (poly I:C) mixed with the stabilizers
carboxymethylcellulose
Carboxymethyl cellulose (CMC) or cellulose gum is a cellulose derivative with carboxymethyl groups (-CH2-COOH) bound to some of the hydroxyl groups of the glucopyranose monomers that make up the cellulose backbone. It is often used as its sodiu ...
and
polylysine.
It is under trial for use in cancer.
Poly I:C is a ligand for
toll like receptor-3, which usually triggers on the structurally similar
double-stranded RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydr ...
present in some viruses.
References
External links
* National Cancer Institute
poly ICLC
Immunostimulants
Combination drugs
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