Piperidione (trade name Sedulon) is a
sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but ...
drug, structurally related to
methyprylon
Methyprylon, or Noludar, is a sedative of the piperidinedione derivative family first developed by Hoffmann-La Roche.
This medicine was used for treating insomnia, but is now rarely used as it has been replaced by newer drugs with fewer side effe ...
and
pyrithyldione
Pyrithyldione (Presidon, Persedon) is a psychoactive drug invented in 1949.
An improved method of manufacture was patented by Roche in 1959. It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. Today, this substa ...
.
It used to be marketed by
Roche
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX ...
as a
cough medicine available in liquid form. In the US, it was approved by the FDA on grounds of safety alone in 1947. After Roche failed to submit evidence of efficacy to the
Drug Efficacy Study Implementation program in 1972, it was withdrawn from the US market.
See also
*
Glutethimide
Glutethimide is a hypnotic sedative that was introduced by Ciba in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused sim ...
References
Withdrawn drugs
Antitussives
2-Piperidinones
GABAA receptor positive allosteric modulators
Sedatives
4-Piperidinones
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