Pipequaline (
INN
Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...
) (developmental code name PK-8165) is an
anxiolytic
An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...
drug that was never marketed.
It possesses a novel
chemical structure
A chemical structure determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid. Molecular geometry refers to the spatial arrangement of ...
that is not closely related to other drugs of this type. The drug has a similar pharmacological profile to the
benzodiazepine family of drugs, but with mainly anxiolytic properties and very little
sedative,
amnestic
Amnesia is a deficit in memory caused by brain damage or disease,Gazzaniga, M., Ivry, R., & Mangun, G. (2009) Cognitive Neuroscience: The biology of the mind. New York: W.W. Norton & Company. but it can also be caused temporarily by the use o ...
or
anticonvulsant effects, and so is classified as a
nonbenzodiazepine anxiolytic.
Pipequaline acts as a non-selective
GABAA receptor
partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...
.
While its profile of anxiolytic effects without sedation would appear to have potential medical applications, pipequaline has never been developed for medical use and is currently only used in scientific research.
See also
*
Indalpine
*
Viqualine
References
Anxiolytics
GABAA receptor positive allosteric modulators
4-Piperidinyl compounds
Quinolines
Sedatives
{{Anxiolytic-stub