Piclozotan (SUN-N4057) is a
selective 5-HT1A receptor partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...
, which has
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...
effects in animal studies. It has been through early clinical trials in humans for treatment of acute
stroke, but results have not yet been announced.
See also
*
Repinotan
*
Robalzotan
Robalzotan (NAD-299, AZD-7371) is a selective antagonist at the 5-HT1A receptor. It was shown to completely reverse the autoreceptor-mediated inhibition of serotonin release induced by the administration of selective serotonin reuptake inhibito ...
References
Carboxamides
Benzoxazepines
2-Pyridyl compounds
Lactams
Organochlorides
Tetrahydropyridines
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