Phenacemide (
INN
Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...
,
BAN) (brand name Phenurone), also known as phenylacetylurea, is an
anticonvulsant of the
ureide
Acylureas (also called ''N''-acylureas or ureides) are a class of chemical compounds formally derived from the acylation of urea.
Uses
Insecticides
A subclass of acylureas known as benzoylureas are insecticides. They act as insect growth regula ...
(acetylurea) class.
It is a
congener and ring-opened
analogue of
phenytoin
Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures (also known as grand mal seizures) and focal seizures, but not absence seizures. The in ...
(a
hydantoin),
and is structurally related to the
barbiturates and to other
hydantoins.
Phenacemide was introduced in 1949 for the treatment of
epilepsy
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Epileptic seizures can vary from brief and nearly undetectable periods to long periods of vigorous shaking due to abnormal electrica ...
, but was eventually withdrawn due to
toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a subs ...
.
See also
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Pheneturide
Pheneturide ( INN, BAN) (brand names Benuride, Deturid, Pheneturid, Septotence, Trinuride), also known as phenylethylacetylurea (or ethylphenacemide), is an anticonvulsant of the ureide class. Conceptually, it can be formed in the body as a metabo ...
References
External links
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Imides
Ureas
Withdrawn drugs
{{anticonvulsant-stub