Perzinfotel (EAA-090) is a drug which acts as a potent

NMDA antagonist NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( NMDAR). They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce ...

. It has

neuroprotective Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...

effects and has been investigated for the treatment of stroke, but lacks analgesic effects. Nevertheless, it shows a good safety profile compared to older drugs, although further development of this drug has been discontinued. Prodrugs were developed since the oral bioavailability of perzinfotel is only around 3-5%.

References

NMDA receptor antagonists Phosphonic acids Quinones Cyclobutenes Nitrogen heterocycles Heterocyclic compounds with 2 rings Enones {{nervous-system-drug-stub