Sir Paul Gordon Fildes (10 February 1882 – 5 February 1971) was a British

pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in t ...

and microbiologist who worked on the development of chemical-

biological weapon A biological agent (also called bio-agent, biological threat agent, biological warfare agent, biological weapon, or bioweapon) is a bacterium, virus, protozoan, parasite, fungus, or toxin that can be used purposefully as a weapon in bioterroris ...

ry at

Porton Down Porton Down is a science park in Wiltshire, England, just northeast of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory (Dstl ...

during the

Second World War World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposi ...

.Fellow list of the Royal Society
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Biography

Early life

Fildes was born in Kensington, London, the son of the artist Sir

Luke Fildes __NOTOC__ Sir Samuel Luke Fildes (3 October 1843 – 28 February 1927) was a British painter and illustrator born in Liverpool and trained at the South Kensington and Royal Academy Schools. He was the grandson of the political activist Mar ...

and great grandson of reformist Mary Fildes, Paul attended Winchester School and then studied surgery at

Trinity College, Cambridge Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge or Oxford. ...

, where he obtained an MB BCh degree.

Career

Fildes served as a

lieutenant-commander Lieutenant commander (also hyphenated lieutenant-commander and abbreviated Lt Cdr, LtCdr. or LCDR) is a commissioned officer rank in many navies. The rank is superior to a lieutenant and subordinate to a commander. The corresponding rank i ...

in the Royal Naval Volunteer Reserve, stationed at the Royal Naval Hospital Haslar (1915–19) during the

First World War World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...

. In 1919 he was made an Officer of the Order of the British Empire. After working at the

London Hospital The Royal London Hospital is a large teaching hospital in Whitechapel in the London Borough of Tower Hamlets. It is part of Barts Health NHS Trust. It provides district general hospital services for the City of London and Tower Hamlets and sp ...

as an assistant bacteriologist, he moved in 1934 to work at the

Middlesex Hospital Middlesex Hospital was a teaching hospital located in the Fitzrovia area of London, England. First opened as the Middlesex Infirmary in 1745 on Windmill Street, it was moved in 1757 to Mortimer Street where it remained until it was finally clos ...

. He was also elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemat ...

in 1934. In 1940 he helped Donald D. Woods discover how

sulphonamides In organic chemistry, the sulfonamide functional group (also spelled sulphonamide) is an organosulfur group with the structure . It consists of a sulfonyl group () connected to an amine group (). Relatively speaking this group is unreactive. B ...

worked. He was a member of the scientific staff, Medical Research Council (1934–49).

World War II

Fildes asserted that he assisted with

Operation Anthropoid On 27 May 1942 in Prague, Reinhard Heydrichthe commander of the Reich Security Main Office (RSHA), acting governor of the Protectorate of Bohemia and Moravia, and a principal architect of the Holocaustwas attacked and wounded in an assassinati ...

the assassination of top Nazi

Reinhard Heydrich Reinhard Tristan Eugen Heydrich ( ; ; 7 March 1904 – 4 June 1942) was a high-ranking German SS and police official during the Nazi era and a principal architect of the Holocaust. He was chief of the Reich Security Main Office (inclu ...

in Prague by providing the

Czech Czech may refer to: * Anything from or related to the Czech Republic, a country in Europe ** Czech language ** Czechs, the people of the area ** Czech culture ** Czech cuisine * One of three mythical brothers, Lech, Czech, and Rus' Places * Czech, ...

agents of the

Special Operations Executive The Special Operations Executive (SOE) was a secret British World War II organisation. It was officially formed on 22 July 1940 under Minister of Economic Warfare Hugh Dalton, from the amalgamation of three existing secret organisations. Its pu ...

with modified No. 73 Grenades filled with

botulin toxin Botulinum toxin, or botulinum neurotoxin (BoNT), is a neurotoxic protein produced by the bacterium ''Clostridium botulinum'' and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromusc ...

. The story has been met with scepticism, given the absence of any indication that Heydrich displayed any of the highly distinctive symptoms of

botulism Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium ''Clostridium botulinum''. The disease begins with weakness, blurred vision, feeling tired, and trouble speaking. This may then be followed by weakne ...

. In 1940 Fildes was put in charge of a newly created department, the Biology Department, Porton (BDP) at

to study the defensive implications of a bacterial attack and there built up a team of microbiologists to study the use of biological weapons, including anthrax and botulinum toxin. An early project was the creation of a stockpile of a million anthrax impregnated cattle cakes to be used in a possible retaliatory attack. In 1942 it famously carried out tests of an anthrax bio-weapon developed at Porton Down at

Gruinard Island Gruinard Island ( ; gd, Eilean Ghruinneard) is a small, oval-shaped Scottish island approximately long by wide, located in Gruinard Bay, about halfway between Gairloch and Ullapool. At its closest point to the mainland, it is about offshore. ...

. He also assisted with the anthrax strain tests on

, performing necropsies on the bodies of anthrax-exposed sheep, to determine if they had died as a direct result of anthrax poisoning. This work produced the world's first working anthrax bomb in the summer of 1942. At the end of the war he returned to university life and handed over control of the department to his deputy David Henderson, who oversaw the building of a new purpose designed laboratory facility and the creation of the autonomous Microbiological Research Department. He was knighted in the

1946 New Year Honours The 1946 New Year Honours were appointments by many of the Commonwealth Realms of King George VI to various orders and honours to reward and highlight good works by citizens of those countries, and to celebrate the passing of 1945 and the beginni ...

Later years

After the war Fildes worked at the Sir William Dunn School of Pathology in Oxford, headed by Nobel Prize winner Sir Howard Florey, to study on the biochemistry of bacteriophage T1 (and to a lesser extent, T2) multiplication. Fildes received the Copley Medal in 1963 from the Royal Society.

Works

He was the author of works on

haemophilia Haemophilia, or hemophilia (), is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding for a longer time after an injury, easy bruising, ...

and syphilis.

References

{{DEFAULTSORT:Fildes, Paul 1882 births 1971 deaths People educated at Winchester College Alumni of Trinity College, Cambridge British microbiologists Fellows of the Royal Society Recipients of the Copley Medal Royal Naval Volunteer Reserve personnel of World War II Knights Bachelor Royal Medal winners Place of birth missing Officers of the Order of the British Empire