PNU-22394 is a drug which acts as an agonist at
serotonin 5-HT
2 receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
s, with strongest binding affinity for
5-HT2A and
5-HT2C and slightly weaker at
5-HT2B, although it is only a full agonist at 5-HT
2C, but partial agonist at 5-HT
2A and 5-HT
2B. It has
anorectic
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic.
The term is (from the Greek ''ἀν-'' (an-) = "without" a ...
effects in both animal studies and human trials,
along with "Pro-Cognitive Properties",
although it has never been developed for medical use.
See also
*
Lorcaserin
Lorcaserin, marketed under the brand name Belviq was a weight-loss drug developed by Arena Pharmaceuticals. It reduces appetite by activating a type of serotonin receptor known as the 5-HT2C receptor in a region of the brain called the hypotha ...
*
Tryptoline
Tryptoline, also known as tetrahydro-β-carboline and tetrahydronorharmane, is a natural organic derivative of ''beta''-carboline. It is an alkaloid chemically related to tryptamines. Derivatives of tryptoline have a variety of pharmacological ...
*
PNU-181731
*
PHA-57378
*
Tabernanthalog
References
Serotonin receptor agonists
Azepines
Tryptamines
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