PD-137889 (''N''-methylhexahydrofluorenamine) is a chemical compound that is active as an

NMDA receptor antagonist NMDA receptor antagonists are a class of drugs that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor ( NMDAR). They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce ...

in the

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...

at roughly 30 times the potency of the "flagship" of its class,

ketamine Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ...

, and substitutes for

phencyclidine Phencyclidine or phenylcyclohexyl piperidine (PCP), also known as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects. PCP may cause hallucinations, distorted percept ...

in animal studies. K''_i'' sup>3HCP binding = 27 nM versus ketamine's K''_i'' = 860 nM.Polycyclic amine derivatives useful as cerebrovascular agents
United States Patent; Coughenour, et al. Family ID: 22686445 Appl. #07/186,834

References

Arylcyclohexylamines Dissociative drugs General anesthetics NMDA receptor antagonists Sedatives Tricyclic compounds {{Sedative-stub

See also

References