PD-0298029 is a drug which acts as a selective

antagonist An antagonist is a character in a story who is presented as the chief foe of the protagonist. Etymology The English word antagonist comes from the Greek ἀνταγωνιστής – ''antagonistēs'', "opponent, competitor, villain, enemy, ri ...

for the muscarinic acetylcholine receptor M₄. It was developed for the treatment of

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms beco ...

, but poor bioavailability and rapid metabolism in animal studies have meant its use is largely limited to ''in vitro'' research into the M₄ and other muscarinic receptors.Progress in Medicinal Chemistry 43. (2005). Chapter 4, Muscarinic Receptor Subtype Pharmacology and Physiology, by Richard M Eglen. pp 128-129.

References

Parkinson's disease Muscarinic antagonists {{nervous-system-drug-stub

See also

References