Otilonium bromide, sold under the trade name Spasmomen among others, is an

antimuscarinic A muscarinic receptor antagonist (MRA) is a type of anticholinergic agent that blocks the activity of the muscarinic acetylcholine receptor. The muscarinic receptor is a protein involved in the transmission of signals through certain parts of th ...

and calcium channel blocker used to relieve spasmodic pain of the gut, especially in

irritable bowel syndrome Irritable bowel syndrome (IBS) is a "disorder of gut-brain interaction" characterized by a group of symptoms that commonly include abdominal pain and or abdominal bloating and changes in the consistency of bowel movements. These symptoms may ...

Medical uses

A pooled analysis of three clinical trials suggest that otilonium is more effective than placebo for the treatment of irritable bowel syndrome.

Pharmacology

Otilinium binds to both

muscarinic receptor Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor, G protein-coupled receptor complexes in the cell membranes of certain neurons and other Cell (biology), cells. They play several r ...

s and tachykinin NK₂ receptors. It has been shown to inhibit L-type and T-type calcium channels, actions which may contribute to or determine its effects in the gut. When taken orally, very little of the drug is absorbed into the rest of the body, which means that most of its actions remain confined to the gastrointestinal system.

References

Muscarinic antagonists Quaternary ammonium compounds Phenol ethers Benzanilides 4-Aminobenzoate esters Bromides {{gastrointestinal-drug-stub