Oswaldo Gonçalves Cruz, better known as Oswaldo Cruz (; August 5, 1872 – February 11, 1917), was a Brazilian

physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...

, pioneer

bacteriologist A bacteriologist is a microbiologist, or similarly trained professional, in bacteriology -- a subdivision of microbiology that studies bacteria, typically pathogenic ones. Bacteriologists are interested in studying and learning about bacteria, ...

epidemiologist Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evid ...

and

public health Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals". Analyzing the det ...

officer and the founder of the

Oswaldo Cruz Institute The Oswaldo Cruz Foundation (Portuguese ''Fundação Oswaldo Cruz'', also known as FIOCRUZ) is a scientific institution for research and development in biological sciences located in Rio de Janeiro, Brazil; it is considered one of the world's ...

. He occupied the fifth chair of the Brazilian Academy of Letters from 1912 until his death in 1917.

Early years

Oswaldo Gonçalves Cruz was born on August 5, 1872 in São Luis do Paraitinga, a small city in São Paulo Province, to the physician Bento Gonçalvez Cruz and Amália Bulhões Cruz. As a child, he moved to Rio de Janeiro with his family. At the age of 15 he started to study at the Faculty of Medicine of Rio de Janeiro and in 1892 he graduated as a medical doctor, with a thesis on water as vehicle for the propagation of

microbes A microorganism, or microbe,, ''mikros'', "small") and ''organism'' from the el, ὀργανισμός, ''organismós'', "organism"). It is usually written as a single word but is sometimes hyphenated (''micro-organism''), especially in olde ...

. Inspired by the work of

Louis Pasteur Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named afte ...

, who had developed the

germ theory The germ theory of disease is the currently accepted scientific theory for many diseases. It states that microorganisms known as pathogens or "germs" can lead to disease. These small organisms, too small to be seen without magnification, invade h ...

disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...

, four years later he went to Paris to specialize in

bacteriology Bacteriology is the branch and specialty of biology that studies the morphology, ecology, genetics and biochemistry of bacteria as well as many other aspects related to them. This subdivision of microbiology involves the identification, classificat ...

at the

Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vacc ...

, which gathered the great names of this branch of science of that time. He was financed by his father-in-law, a wealthy Portuguese merchant.

Career

Work in Brazil

Cruz found that the seaport of Santos was ravaged by an

epidemic An epidemic (from Greek ἐπί ''epi'' "upon or above" and δῆμος ''demos'' "people") is the rapid spread of disease to a large number of patients among a given population within an area in a short period of time. Epidemics of infectious ...

bubonic plague Bubonic plague is one of three types of plague caused by the plague bacterium ('' Yersinia pestis''). One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever, headaches, and vomiting, as wel ...

that threatened to reach Rio de Janeiro, and engaged himself immediately in the combat of this disease. The mayor of

Rio de Janeiro Rio de Janeiro ( , , ; literally 'River of January'), or simply Rio, is the capital of the state of the same name, Brazil's third-most populous state, and the second-most populous city in Brazil, after São Paulo. Listed by the GaWC as a b ...

authorized the construction of a plant for manufacturing the serum against the disease which had been developed at the Pasteur Institute by

Alexandre Yersin Alexandre Emile Jean Yersin (22 September 1863 – 1 March 1943) was a Swiss-French physician and bacteriologist. He is remembered as the co-discoverer of the bacillus responsible for the bubonic plague or pest, which was later named in his ...

and coworkers. He asked the institution for a scientist who could bring this know-how to Brazil. The Pasteur Institute responded that such a person was already available in Brazil: Dr. Oswaldo Cruz. On May 25, 1900, the Federal

Serum Serum may refer to: * Serum (blood), plasma from which the clotting proteins have been removed **Antiserum, blood serum with specific antibodies for passive immunity * Serous fluid, any clear bodily fluid *Truth serum, a drug that is likely to mak ...

Therapy Institute was created, intended for the production of sera and

vaccine A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified.

s against the bubonic plague, with Baron Pedro Afonso as director general and the young bacteriologist Oswaldo Cruz as technical director. The new institute was established in the old farm of Manguinhos at the western shores of

Guanabara Bay Guanabara Bay ( pt, Baía de Guanabara, ) is an oceanic bay located in Southeast Brazil in the state of Rio de Janeiro. On its western shore lie the cities of Rio de Janeiro and Duque de Caxias, and on its eastern shore the cities of Niterói a ...

. In 1902, Cruz accepted the office of director general of the institute and soon expanded the scope of its activities, now no longer restricted to the production of sera but also dedicated to basic and applied research and to the building of human resources. In the following year, Cruz was appointed director general of Public Health, a position corresponding to today's Brazilian Minister of Health. Using the Federal Serum Therapy Institute as a technical-scientific base, he embarked on a quick succession of important

sanitation Sanitation refers to public health conditions related to clean drinking water and treatment and disposal of human excreta and sewage. Preventing human contact with feces is part of sanitation, as is hand washing with soap. Sanitation syste ...

campaigns. His first challenge was a series of

yellow fever Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. ...

endemics, which had earned Rio de Janeiro the sinister reputation of 'Foreigners' Grave'. Between 1897 and 1906, 4,000 European immigrants had died there from the disease. Cruz pursued the new technique of eradicating mosquitoes and their breeding grounds, fumigating houses, and isolation of the ill. There was opposition to the campaign by many, including physicians, the military, and the poor, but the campaign was successful. Cruz was initially successful in the sanitary campaign against the bubonic plague, to which end he used obligatory notification of cases, isolation of sick people, treatment with the sera produced at Manguinhos and extermination of the rats populating the city.

Smallpox vaccination controversy

He was not successful in implementing a widespread vaccination against

smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...

, due to popular resistance to it.Stepan, "Cruz", p. 303. In 1904, a

epidemic was threatening the capital. In the first five months of the year, more than 1,800 people had been hospitalized. A law imposing smallpox vaccination of children had existed since 1837 but had never been put into practice. Therefore, on June 9, 1904, following a proposal by Oswaldo Cruz, the government presented a bill to the Congress requesting the reestablishment of obligatory smallpox vaccination. The extremely rigid and severe provisions of this instrument terrified the people. Popular opposition against Cruz increased sharply and opposition newspapers started a violent campaign against this and the federal government in general. Members of the parliament and labor unions protested. An anti-vaccination league was organized. On November 10, the

Vaccine Revolt The Vaccine Revolt or Vaccine Rebellion (Portuguese: ''Revolta da Vacina'') was a period of civil disorder which occurred in the city of Rio de Janeiro, Brazil (November 10–18, 1904). Background At the beginning of the 20th century the city o ...

exploded in Rio. Violent confrontations with the police ensued, with

strike Strike may refer to: People * Strike (surname) Physical confrontation or removal *Strike (attack), attack with an inanimate object or a part of the human body intended to cause harm *Airstrike, military strike by air forces on either a suspected ...

barricade Barricade (from the French ''barrique'' - 'barrel') is any object or structure that creates a barrier or obstacle to control, block passage or force the flow of traffic in the desired direction. Adopted as a military term, a barricade denot ...

s, and shootings in the streets, as the population rose in protest against the government. On November 14, the cadets of the Military Academy joined the revolt, but were dispersed after intense shooting. The government declared a

state of siege A state of emergency is a situation in which a government is empowered to be able to put through policies that it would normally not be permitted to do, for the safety and protection of its citizens. A government can declare such a state du ...

. On November 16, the uprising was controlled, but the obligatory vaccination was suspended. In 1908, a violent smallpox epidemic made the people rush en masse to the vaccination units. Some 9,000 people died. Cruz was vindicated and his merit recognized.

Later work

Among the international scientific community, his prestige was already uncontested. In 1907, on occasion of the 14th International Congress on Hygiene and Demography in Berlin, Cruz was awarded with the gold medal in recognition of the sanitation of Rio de Janeiro. In 1909, he retired from the position as director general for Public Health, dedicating himself exclusively to the Manguinhos Institute, which has been named after him. From the institute he organized important scientific expeditions, which allowed a better knowledge about the health and life conditions in the interior of the country and contributed to the colonization of regions. Cruz eradicated urban yellow fever in the state of

Pará Pará is a state of Brazil, located in northern Brazil and traversed by the lower Amazon River. It borders the Brazilian states of Amapá, Maranhão, Tocantins, Mato Grosso, Amazonas and Roraima. To the northwest are the borders of Guyana a ...

. His sanitation campaign in the state of Amazonas allowed the completion of construction of the Madeira-Mamoré

railroad Rail transport (also known as train transport) is a means of transport that transfers passengers and goods on wheeled vehicles running on rails, which are incorporated in tracks. In contrast to road transport, where the vehicles run on a prep ...

, which had been interrupted due to the great number of deaths from

malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. ...

and yellow fever among the workers. In 1913, Cruz was elected a member of the Brazilian Academy of Arts and Letters. In 1915, due to health problems, he resigned from the directorship of the Oswaldo Cruz Institute and moved to Petrópolis, a small city in the mountains near Rio. On August 18, 1916, he was elected mayor of that city and outlined an extensive

urbanization Urbanization (or urbanisation) refers to the population shift from rural to urban areas, the corresponding decrease in the proportion of people living in rural areas, and the ways in which societies adapt to this change. It is predominantly th ...

project he would not see implemented.

Death and legacy

In the morning of February 11, 1917, at 44 years of age, he died of

kidney failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...

in Petrópolis,

state. As a consequence of the short, fruitful life of Dr. Oswaldo Cruz, an extremely important scientific and health institution was born, which marked the beginning of experimental medicine in Brazil in many areas. To this day it exerts a strong influence on Brazilian science, technology and

References

* Buss, Paulo (June 2001)
The Oswaldo Cruz Foundation: 100 years
''TDRNews'' 65. Retrieved 2005-03-02.

at '' ttp://www.fiocruz.br/ FIOCRUZ: Oswald Cruz Foundation'. Retrieved 2005-03-02. (''website in Portuguese with English section'')

External links

Cruz on the Brazilian 50 Cruzados banknote

Museum of Life (online exhibition on Oswaldo Cruz
{{DEFAULTSORT:Cruz, Oswaldo 1872 births 1917 deaths People from São Paulo (state) Brazilian public health doctors Deaths from kidney failure Members of the Brazilian Academy of Letters 19th-century Brazilian scientists 20th-century Brazilian scientists Brazilian bacteriologists