ORG-21465 is a synthetic
neuroactive steroid, with
sedative effects resulting from its action as a
GABAA receptor positive allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...
. It is similar to related drugs such as
ORG-20599, and was similarly developed as an improved alternative to other sedative steroids such as
althesin and
allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.
Chemistry
See also
*
ORG-25435
References
Neurosteroids
Anticonvulsants
Hypnotics
Morpholines
GABAA receptor positive allosteric modulators
Pregnanes
{{Sedative-stub