Oleh Hornykiewicz (17 November 1926 - 26 May 2020) was an Austrian biochemist.

Life

Oleh Hornykiewicz was born in 1926 in Sykhiw (a district of

Lviv Lviv ( uk, Львів) is the largest city in western Ukraine, and the seventh-largest in Ukraine, with a population of . It serves as the administrative centre of Lviv Oblast and Lviv Raion, and is one of the main cultural centres of Ukrain ...

), then in

Poland Poland, officially the Republic of Poland, is a country in Central Europe. It is divided into 16 administrative provinces called voivodeships, covering an area of . Poland has a population of over 38 million and is the fifth-most populou ...

(now

Ukraine Ukraine ( uk, Україна, Ukraïna, ) is a country in Eastern Europe. It is the second-largest European country after Russia, which it borders to the east and northeast. Ukraine covers approximately . Prior to the ongoing Russian inv ...

). In 1951, he received his M.D. degree from the

University of Vienna The University of Vienna (german: Universität Wien) is a public research university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world. With its long and rich hist ...

and joined the faculty of his alma mater the same year and worked there ever since. He also served for twenty years as chairman of the Institute of Biochemical Pharmacology. In 1967, he began a long association with the

University of Toronto The University of Toronto (UToronto or U of T) is a public university, public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park (Toronto), Queen's Park. It was founded by royal charter in 1827 ...

Canada Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by tot ...

and, in 1992, he was named professor emeritus at that institution. One of his seminal accomplishments was the discovery that

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms usually emerge slowly, and as the disease worsens, non-motor symptoms becom ...

was due to dopamine deficiency in the brain. He also played a key role in the development of

L-dopa -DOPA, also known as levodopa and -3,4-dihydroxyphenylalanine, is an amino acid that is made and used as part of the normal biology of some plants and animals, including humans. Humans, as well as a portion of the other animals that utilize -DOPA ...

as a therapy for the disorder.

Awards

*1972

Gairdner Foundation International Award The Canada Gairdner International Award is given annually by the Gairdner Foundation at a special dinner to five individuals for outstanding discoveries or contributions to medical science. Receipt of the Gairdner is traditionally considered a ...

*1979

Wolf Prize in Medicine The Wolf Prize in Medicine is awarded annually by the Wolf Foundation in Israel. It is one of the six Wolf Prizes established by the Foundation and awarded since 1978; the others are in Agriculture, Chemistry, Mathematics, Physics and Arts. The ...

, jointly with

Roger Wolcott Sperry Roger Wolcott Sperry (August 20, 1913 – April 17, 1994) was an American neuropsychologist, neurobiologist, cognitive neuroscientist, and Nobel laureate who, together with David Hunter Hubel and Torsten Nils Wiesel, won the 1981 Nobel Prize ...

and

Arvid Carlsson Arvid Carlsson (25 January 1923 – 29 June 2018) was a Swedish neuropharmacologist who is best known for his work with the neurotransmitter dopamine and its effects in Parkinson's disease. For his work on dopamine, Carlsson was awarded the Nobe ...

, "for opening a new approach in the control of Parkinson's disease by L-Dopa." *1993 Ludwig Wittgenstein Prize of the Austrian Science Foundation *1994 Schmiedeberg Medal of the German Society for Experimental and Clinical Pharmacology and Toxicology *2001 Bill Roth Medal *2008

Austrian Cross of Honour for Science and Art, 1st class The Austrian Decoration for Science and Art (german: Österreichisches Ehrenzeichen für Wissenschaft und Kunst) is a state decoration of the Republic of Austria and forms part of the Austrian national honours system. History The "Austrian D ...

*2010

Austrian Decoration for Science and Art The Austrian Decoration for Science and Art (german: Österreichisches Ehrenzeichen für Wissenschaft und Kunst) is a state decoration of the Republic of Austria and forms part of the Austrian national honours system. History The "Austrian ...

* 2014

Warren Alpert Foundation Prize The Warren Alpert Foundation Prize is awarded annually to scientist(s) whose scientific achievements have led to the prevention, cure or treatment of human diseases or disorders, and/or whose research constitutes a seminal scientific finding that ho ...

Warren Alpert Foundation Prize Recognizes Leaders in Brain Research
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References

1926 births 2020 deaths Scientists from Lviv Austrian biochemists University of Vienna alumni Academics of the University of Vienna Wolf Prize in Medicine laureates Recipients of the Austrian Decoration for Science and Art Austrian people of Ukrainian descent {{Austria-med-bio-stub