Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''NTF4''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
It is a
neurotrophic factor that signals predominantly through the
TrkB receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high- affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kin ...
.
See also
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Tropomyosin receptor kinase B ยง Agonists
References
Further reading
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External links
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Neurotrophic factors
Peptide hormones
Growth factors
Developmental neuroscience
Proteins
TrkB agonists
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