NS-11394 is a drug which acts as a subtype-selective
positive allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...
at
GABAA receptors, with selectivity for the
α3 and
α5 subtypes.
It has been researched as an
analgesic for use in chronic or
neuropathic pain
Neuropathic pain is pain caused by damage or disease affecting the somatosensory system. Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia). It may have continuous ...
.
References
{{GABAAR PAMs
Analgesics
GABAA receptor positive allosteric modulators