NBUMP is a highly selective 5-HT_1A receptor

partial agonist In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...

(K_i = 0.1 nM; IA = 40%) with an

aryl In organic chemistry, an aryl is any functional group or substituent derived from an aromaticity, aromatic ring, usually an aromatic hydrocarbon, such as phenyl and naphthyl. "Aryl" is used for the sake of abbreviation or generalization, and "Ar ...

piperazine Piperazine () is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste. The piperazines are a broad ...

structure. It is one of the highest

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ligands for the 5-HT_1A receptor known. It displays 460- and 260-fold selectivity for 5-HT_1A over the α₁-adrenergic and D₂ receptors, respectively.

References

{{Piperazines Phenylpiperazines 5-HT1A agonists Serotonin receptor agonists Adamantanes Carboxamides Phenol ethers

See also

References