''N''-Methyltryptamine (NMT) is a member of the substituted tryptamine chemical class and a natural product which is

biosynthesized Biosynthesis is a multi-step, enzyme- catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined to form macromolecules ...

in the human body from

tryptamine Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole ─ a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the f ...

by certain

N-methyltransferase N-methyltransferase may refer to: * (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase * 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase * Amine N-methyltransferase * Anthranilate N-methyltransferase * (cytochrome c)-a ...

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

s, such as indolethylamine ''N''-methyltransferase. It is a common component in human urine. NMT is an

alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...

derived from L-tryptophan that has been found in the bark,

shoot In botany, a plant shoot consists of any plant stem together with its appendages, leaves and lateral buds, flowering stems, and flower buds. The new growth from seed germination that grows upward is a shoot where leaves will develop. In the sp ...

s and leaves of several plant genera, including ''

Virola ''Virola'' is a genus of medium-sized trees native to the South American rainforest and closely related to other Myristicaceae, such as nutmeg. Species are known commonly as ''epená'', ''patricá'', or ''cumala''. They have glossy, dark green le ...

'', '' Acacia'', ''

Mimosa ''Mimosa'' is a genus of about 590 species of herbs and shrubs, in the mimosoid clade of the legume family Fabaceae. The generic name is derived from the Greek word (''mimos''), an "actor" or "mime", and the feminine suffix -''osa'', "resemb ...

'', and '' Desmanthus''—often together with the related

compound Compound may refer to: Architecture and built environments * Compound (enclosure), a cluster of buildings having a shared purpose, usually inside a fence or wall ** Compound (fortification), a version of the above fortified with defensive struc ...

s ''N'',''N''-dimethyltryptamine (DMT) and 5-methoxy-''N'',''N''-dimethyltryptamine (5-MeO-DMT). Orally administered NMT appears to produce no psychoactive effects, likely as a result of extensive

first-pass metabolism The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug, specifically when administered orally, is greatly reduced before it reaches the system ...

.Foye's principles of medicinal chemistry By William O. Foye, Thomas L. Lemke, David A. Williams However, it may become

active Active may refer to: Music * ''Active'' (album), a 1992 album by Casiopea * Active Records, a record label Ships * ''Active'' (ship), several commercial ships by that name * HMS ''Active'', the name of various ships of the British Royal ...

upon

combination In mathematics, a combination is a selection of items from a set that has distinct members, such that the order of selection does not matter (unlike permutations). For example, given three fruits, say an apple, an orange and a pear, there are th ...

with a MAO_A inhibitor (MAOI). By vaporization NMT shows activity at 50–100 mg, with a duration of 45–70 minutes; duration of visual effects 15–30 seconds. Effects are primarily non-visual.Nen - lecture presented EGA conference, Victoria, Australia 4/12/2011; and Breaking Conventions, London 12/7/2013.

References

External links

NMT Entry in ''TIHKAL''

NMT Entry in TiHKAL • info
{{DEFAULTSORT:Methyltryptamine, N- Tryptamine alkaloids Psychedelic tryptamines Serotonin receptor agonists

See also

References

External links