''Muromegalovirus'' is a genus of

viruses A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's ...

in the order ''

Herpesvirales The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans ...

'', in the family ''

Herpesviridae ''Herpesviridae'' is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ''ἕρπει� ...

'', in the subfamily ''

Betaherpesvirinae ''Betaherpesvirinae'' is a subfamily of viruses in the order ''Herpesvirales'' and in the family ''Herpesviridae''. Mammals serve as natural hosts. There are 26 species in this subfamily, divided among 5 genera. Diseases associated with this sub ...

''. Rodents serve as natural hosts. There are three species in this genus. Diseases associated with this genus include: infected peritoneal macrophages, dendritic cells (DC) and hepatocytes, inducing significant pathology in both the spleen and the liver.

Murid In Sufism, a ''murīd'' (Arabic مُرِيد 'one who seeks') is a novice committed to spiritual enlightenment by ''sulūk'' (traversing a path) under a spiritual guide, who may take the title murshid, '' pir'' or ''shaykh''. A ''sālik'' or Su ...

viruses ''

Murid betaherpesvirus 1 ''Murid betaherpesvirus 1'' (MuHV-1) is a species of virus in the genus ''Muromegalovirus'', subfamily ''Betaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore gro ...

'' (MuHV-1) and ''

Murid betaherpesvirus 2 ''Murid betaherpesvirus 2'' (MuHV-2) is a species of virus in the genus ''Muromegalovirus'', subfamily ''Betaherpesvirinae'', family ''Herpesviridae'', and order ''Herpesvirales The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore gro ...

'' (MuHV-2), previously defined as mouse cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV), belong to this genus.

Species

The genus consists of the following three species: * ''

'' * ''

'' * '' Murid betaherpesvirus 8''

Structure

Viruses in ''Muromegalovirus'' are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 230kb in length.

Life cycle

Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding. Rodents serve as the natural host.

References

External links

Viralzone: ''Muromegalovirus''

ICTV
{{Use dmy dates, date=April 2017 Betaherpesvirinae Animal viral diseases Virus genera Rodent diseases