Minaxolone (CCI-12923) is a
neuroactive steroid which was developed as a
general anesthetic
General anaesthetics (or anesthetics, see spelling differences) are often defined as compounds that induce a loss of consciousness in humans or loss of righting reflex in animals. Clinical definitions are also extended to include an induced coma ...
but was withdrawn before registration due to
toxicity
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a subs ...
seen with long-term administration in rats, and hence was never marketed.
It is a
positive allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...
of the
GABAA receptor,
as well as, less potently, a positive allosteric modulator of the
glycine receptor.
Chemistry
See also
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Alfadolone
*
Alfaxolone
*
Ganaxolone
Ganaxolone, sold under the brand name Ztalmy, is a medication used to treat seizures in people with cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD).
Ganaxolone was approved for medical use in the United States in March 2022. ...
*
Hydroxydione
Hydroxydione, as hydroxydione sodium succinate (, , ) (brand names Viadril, Predion, and Presuren), also known as 21-Hydroxy-5β-pregnane-3,20-dione, is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued ...
*
Pregnanolone
*
Renanolone
Renanolone ( INN), or 11-ketopregnanolone, also known as 5β-pregnan-3α-ol-11,20-dione, is a synthetic neuroactive steroid which is described as a general anesthetic but was never introduced for clinical use. Its isomers, alfaxolone and alfadolon ...
References
General anesthetics
Neurosteroids
Secondary alcohols
Ethers
Dimethylamino compounds
Ketones
GABAA receptor positive allosteric modulators
Glycine receptor agonists
Pregnanes
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