Methitural on:
[Wikipedia]
[Google]
[Amazon]
Methitural (International Nonproprietary Name, INN; Neraval, Thiogenal), or methitural sodium, also known as methioturiate, is a barbiturate chemical derivative, derivative which was marketed in the 1950s in Europe (in Germany and Italy) as an ultra-short-acting intravenous anesthetic.
A somewhat more complex side chain is incorporated by alkylation of the carbanion of the substituted cyanoacetate (1) with 2-chloroethylmethyl sulfide (2). Condensation of the resulting cyanoester (3) with thiourea followed by hydrolysis of the resulting imine affords methitural.
Synthesis
A somewhat more complex side chain is incorporated by alkylation of the carbanion of the substituted cyanoacetate (1) with 2-chloroethylmethyl sulfide (2). Condensation of the resulting cyanoester (3) with thiourea followed by hydrolysis of the resulting imine affords methitural.
See also
* BarbiturateReferences
General anesthetics Thiobarbiturates GABAA receptor positive allosteric modulators {{sedative-stub