Melanin-concentrating hormone receptor 2 (MCH₂) also known as G-protein coupled receptor 145 (GPR145) is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

that in humans is encoded by the ''MCHR2''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. MCH₂ is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH₂ gene and its receptor product.

Clinical significance

Treatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of

INSIG2 Insulin induced gene 2, also known as INSIG2, is a protein which in humans is encoded by the ''INSIG2'' gene. Regulation Insulin activates the human INSIG2 promoter in a process mediated by phosphorylated SAP1a. Akt mediates suppression of ...

and ACOT8.

Clinical significance

See also

References

External links

Further reading