MacFarlan Smith is a

pharmaceutical research Pharmacy is the science and practice of discovering, producing, preparing, dispensing, reviewing and monitoring medications, aiming to ensure the safe, effective, and affordable use of medicines. It is a miscellaneous science as it links hea ...

company based in

Edinburgh Edinburgh ( ; gd, Dùn Èideann ) is the capital city of Scotland and one of its 32 Council areas of Scotland, council areas. Historically part of the county of Midlothian (interchangeably Edinburghshire before 1921), it is located in Lothian ...

, Scotland, founded in 1815. It is part of the Fine Chemical and Catalysts division of

Johnson Matthey Johnson Matthey is a British multinational speciality chemicals and sustainable technologies company headquartered in London, England. It is listed on the London Stock Exchange and is a constituent of the FTSE 250 Index. History Early years Jo ...

Background

J.F. Macfarlan

J.F. Macfarlan Ltd was founded in 1780 as an

apothecary ''Apothecary'' () is a mostly archaic term for a medical professional who formulates and dispenses '' materia medica'' (medicine) to physicians, surgeons, and patients. The modern chemist (British English) or pharmacist (British and North Amer ...

supplier. In 1815 John Fletcher Macfarlan, licentiate of the

Royal College of Surgeons The Royal College of Surgeons is an ancient college (a form of corporation) established in England to regulate the activity of surgeons. Derivative organisations survive in many present and former members of the Commonwealth. These organisations ...

, became the owner of the family business, and acquired an apothecary's shop in Edinburgh. He immediately began to manufacture

laudanum Laudanum is a tincture of opium containing approximately 10% powdered opium by weight (the equivalent of 1% morphine). Laudanum is prepared by dissolving extracts from the opium poppy (''Papaver somniferum Linnaeus'') in alcohol (ethanol). R ...

, a medicine based on

opium Opium (or poppy tears, scientific name: ''Lachryma papaveris'') is dried latex obtained from the seed capsules of the opium poppy '' Papaver somniferum''. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which ...

. In 1830 Macfarlan began a partnership with his former apprentice David Rennie Brown, and so incorporated the business as J.F. Macfarlan and Co Ltd. In 1832 the company began manufacture of

morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies ('' Papaver somniferum''). It is mainly used as a pain medication, and is also commonly used recreationally, or to make other illicit opioids. T ...

acetate (the medicinal version of

heroin Heroin, also known as diacetylmorphine and diamorphine among other names, is a potent opioid mainly used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt. Various white and bro ...

) and

hydrochloride In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative n ...

, which led to the development and manufacture of the

anaesthetic An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness. They may be divided into two ...

ether In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again ...

and

chloroform Chloroform, or trichloromethane, is an organic compound with formula C H Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to PTFE. It is also a precursor to various ...

. This allowed the company to develop sterile dressings for

Joseph Lister, 1st Baron Lister Joseph Lister, 1st Baron Lister, (5 April 182710 February 1912) was a British surgeon, medical scientist, experimental pathologist and a pioneer of antiseptic surgery and preventative medicine. Joseph Lister revolutionised the craft of su ...

under contract. After acquiring the Abbeyhill chemical works in 1840 for the production of

alkaloids Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...

, from 1870 the production of

codeine Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is also commonly used as a recreational drug. It is found naturally in the sap of the opium poppy, ''Papaver somniferum''. It is typically ...

began in 1886. The company then acquired another site in

Northfield, Edinburgh Northfield is a suburb of Edinburgh, the capital of Scotland. It lies east of the city centre and west of Portobello. The area was laid out at low densities as local authority housing but the city employed private architects for its design - ...

, in 1900 for the production of

strychnine Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the e ...

Duncan Flockhart

John Duncan was born in

Kinross Kinross (, gd, Ceann Rois) is a burgh in Perth and Kinross, Scotland, around south of Perth and around northwest of Edinburgh. It is the traditional county town of the historic county of Kinross-shire. History Kinross's origins are c ...

in 1780. After serving a five-year apprenticeship in Edinburgh, he moved directly to London, before returning to

Perth Perth is the capital and largest city of the Australian state of Western Australia. It is the fourth most populous city in Australia and Oceania, with a population of 2.1 million (80% of the state) living in Greater Perth in 2020. Perth is ...

in 1806 to establish a chemists shop. After expanding to Edinburgh in 1820, Duncan dissolved the partnership with the Perth shop and started a new partnership in Edinburgh with William Flockhart (also from Kinross), which in 1833 was called Duncan & Flockhart, incorporated three years later. Following the death of John Duncan (c. 1839) the firm was taken over by his son Dr James Duncan. In the same year the firm began to manufacture lactucarium, and from 1847 supplied

Chloroform Chloroform, or trichloromethane, is an organic compound with formula C H Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to PTFE. It is also a precursor to various ...

to Sir James Simpson. The firm expanded, and supplied chloroform to both the

British Army The British Army is the principal land warfare force of the United Kingdom, a part of the British Armed Forces along with the Royal Navy and the Royal Air Force. , the British Army comprises 79,380 regular full-time personnel, 4,090 Gurkha ...

Royal Navy The Royal Navy (RN) is the United Kingdom's naval warfare force. Although warships were used by English and Scottish kings from the early medieval period, the first major maritime engagements were fought in the Hundred Years' War against Fr ...

and

British Red Cross The British Red Cross Society is the United Kingdom body of the worldwide neutral and impartial humanitarian network the International Red Cross and Red Crescent Movement. The society was formed in 1870, and is a registered charity with mor ...

during both world wars. After the start of

World War I World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was List of wars and anthropogenic disasters by death toll, one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, ...

, the company established a drug growing farm at

Warriston Warriston ( ) is a suburb of Edinburgh, the capital of Scotland. It lies east of the Royal Botanic Garden in Inverleith. The name derives from Warriston House, a local mansion house demolished in 1966. In July 1600 John Kincaid, the Laird o ...

, to assure supply.

T&H Smith

T&H Smith was established as a chemists at 21-23 Duke Street, Edinburgh in 1827, by Thomas Smith and his brother Henry. On 13 April 1839, just three months after

Henry Fox Talbot William Henry Fox Talbot FRS FRSE FRAS (; 11 February 180017 September 1877) was an English scientist, inventor, and photography pioneer who invented the salted paper and calotype processes, precursors to photographic processes of the later 1 ...

had announced his ''photogenic drawing'' process, T&H Smith placed an advert in ''

The Scotsman ''The Scotsman'' is a Scottish compact newspaper and daily news website headquartered in Edinburgh. First established as a radical political paper in 1817, it began daily publication in 1855 and remained a broadsheet until August 2004. Its pare ...

'' offering photographic paper and chemicals. In 1840, having bought Blandfields Chemicals in

Canongate The Canongate is a street and associated district in central Edinburgh, the capital city of Scotland. The street forms the main eastern length of the Royal Mile while the district is the main eastern section of Old Town, Edinburgh, Edinburgh's ...

and moved into their premises, the company developed the first liquid essence of

coffee Coffee is a drink prepared from roasted coffee beans. Darkly colored, bitter, and slightly acidic, coffee has a stimulating effect on humans, primarily due to its caffeine content. It is the most popular hot drink in the world. Seeds of ...

, later supplemented by creating various carbonated beverage flavours. Having opened a London branch in 1848, in 1851 the company discovered

Aloin Aloin, also known as barbaloin, is a bitter, yellow-brown colored compound noted in the exudate of at least 68 ''Aloe'' species at levels from 0.1 to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 spec ...

. But the company fortunes were made from 1855, when the first

Morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies ('' Papaver somniferum''). It is mainly used as a pain medication, and is also commonly used recreationally, or to make other illicit opioids. T ...

injection was developed. T&H Smith was the first company to produce commercial quantities of

Apomorphine Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non- selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. It also acts as an antag ...

, and then

Diamorphine Heroin, also known as diacetylmorphine and diamorphine among other names, is a potent opioid mainly used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt. Various white and brown ...

in 1887. In 1906 the company moved from Canongate to the suburban outskirts of Edinburgh at Gorgie. During

, the company supplied Morphine and over of Lint-based

medical dressing A dressing is a sterile pad or compress applied to a wound to promote healing and protect the wound from further harm. A dressing is designed to be in direct contact with the wound, as distinguished from a bandage, which is most often used to hold ...

s to the

. In 1919, T&H Smith bought Glasgow Apothecaries. In 1926, the company acquired John Mackay Chemicals, subsequently incorporating its associated subsidiaries in

Australia Australia, officially the Commonwealth of Australia, is a sovereign country comprising the mainland of the Australian continent, the island of Tasmania, and numerous smaller islands. With an area of , Australia is the largest country by ...

Canada Canada is a country in North America. Its ten provinces and three territories extend from the Atlantic Ocean to the Pacific Ocean and northward into the Arctic Ocean, covering over , making it the world's second-largest country by to ...

and

New Zealand New Zealand ( mi, Aotearoa ) is an island country in the southwestern Pacific Ocean. It consists of two main landmasses—the North Island () and the South Island ()—and over 700 smaller islands. It is the sixth-largest island coun ...

Foundation

In 1962, T&H Smith bought Duncan Flockhart, and then merged with along J.F Macfarlan to form Edinburgh Pharmaceuticals. In 1965 the

Glaxo Group GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham. GSK is the tent ...

bought Edinburgh Pharmaceuticals, rebranding it Macfarlan Smith Ltd. In 1958, while trying to develop dental anesthetic

Lignocaine Lidocaine, also known as lignocaine and sold under the brand name Xylocaine among others, is a local anesthetic of the amino amide type. It is also used to treat ventricular tachycardia. When used for local anaesthesia or in nerve blocks, lidoca ...

, the company had discovered the bitterest known substance,

Denatonium Denatonium, usually available as denatonium benzoate (under trade names such as Denatrol, BITTERANT-b, BITTER+PLUS, ''Bitrex'', and ''Aversion'') and as denatonium saccharide (BITTERANT-s), is the most bitter chemical compound known, with bitterne ...

. Developed as a denaturant for

industrial alcohol Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a hy ...

, in the 1970s it was commercial marketed as Bitrex, a safety additive for household products such as liquid detergents.

Tesco Tesco plc () is a British Multinational corporation, multinational groceries and general merchandise retailer headquartered in Welwyn Garden City, England. In 2011 it was the third-largest retailer in the world measured by gross revenues an ...

was the first supermarket to display the Bitrex brand on their products. In 1963 the company reproduced

Etorphine Etorphine (M99) is a semi-synthetic opioid possessing an analgesic potency approximately 1,000–3,000 times that of morphine. It was first prepared in 1960 from oripavine, which does not generally occur in opium poppy extract but rather the ...

, in a research group led by Professor Kenneth Bentley. Bought through a

management buy out A management buyout (MBO) is a form of acquisition in which a company's existing managers acquire a large part, or all, of the company, whether from a parent company or individual. Management-, and/or leveraged buyout became noted phenomena of 19 ...

in 1990, Macfarlan Smith was floated on the

London Stock Exchange London Stock Exchange (LSE) is a stock exchange in the City of London, England, United Kingdom. , the total market value of all companies trading on LSE was £3.9 trillion. Its current premises are situated in Paternoster Square close to St Pau ...

in 1993 under the holding company Meconic, the

Greek language Greek ( el, label= Modern Greek, Ελληνικά, Elliniká, ; grc, Ἑλληνική, Hellēnikḗ) is an independent branch of the Indo-European family of languages, native to Greece, Cyprus, southern Italy ( Calabria and Salento), souther ...

word for

poppy A poppy is a flowering plant in the subfamily Papaveroideae of the family Papaveraceae. Poppies are herbaceous plants, often grown for their colourful flowers. One species of poppy, '' Papaver somniferum'', is the source of the narcotic drug o ...

Present

In 2001,

plc bought Meconic, and merged it into its Fine Chemical and Catalysts division. In late 2006, the

British government ga, Rialtas a Shoilse gd, Riaghaltas a Mhòrachd , image = HM Government logo.svg , image_size = 220px , image2 = Royal Coat of Arms of the United Kingdom (HM Government).svg , image_size2 = 180px , caption = Royal Arms , date_est ...

permitted MacFarlan Smith to cultivate opium poppies in the United Kingdom for medicinal reasons, in response to increasing global prices for concentrate of poppy straw, the company's main raw material. A major opium poppy field is based in

Didcot Didcot ( ) is a railway town and Civil parishes in England, civil parish in the Ceremonial counties of England, ceremonial county of Oxfordshire and the Historic counties of England, historic county of Berkshire. Didcot is south of Oxford, eas ...

, England. As of 2012 they were growing in Dorset, Hampshire, Oxfordshire & Lincolnshire as a spring sown breakcrop recognised under the single payment scheme farm subsidy. The

Office of Fair Trading The Office of Fair Trading (OFT) was a non-ministerial government department of the United Kingdom, established by the Fair Trading Act 1973, which enforced both consumer protection and competition law, acting as the United Kingdom's economic regu ...

has alerted the government to their monopoly position on growing in the UK and worldwide production of

diamorphine Heroin, also known as diacetylmorphine and diamorphine among other names, is a potent opioid mainly used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt. Various white and brown ...

and recommended consideration. The government's response advocated the status quo, being concerned interference might cause the company to stop production. The British government has since contradicted the Home Office's suggestion that opium cultivation can be legalized in

Afghanistan Afghanistan, officially the Islamic Emirate of Afghanistan,; prs, امارت اسلامی افغانستان is a landlocked country located at the crossroads of Central Asia and South Asia. Referred to as the Heart of Asia, it is borde ...

for exports to the United Kingdom, helping lower poverty and internal fighting whilst helping the

National Health Service The National Health Service (NHS) is the umbrella term for the publicly funded healthcare systems of the United Kingdom (UK). Since 1948, they have been funded out of general taxation. There are three systems which are referred to using the " ...

to meet the high demand for

and

. Opium poppy cultivation in the United Kingdom does not need a licence, but a licence is required for those wishing to extract opium for medicinal products.The painkilling fields: England's opium poppies that tackle the NHS morphine crisis
Press release
, 15 September 2007. Macfarlan Smith is now one of the world's leading manufacturer of opiate alkaloids. Together with sister companies within the Johnson Matthey group, they can provide full spectrum drug development, from drug discovery through to bulk production.

References

External links

Company website

Bitrex website
{{Authority control British companies established in 1815 1815 establishments in Scotland Gorgie Companies based in Edinburgh Pharmaceutical companies of Scotland Companies formerly listed on the London Stock Exchange GSK plc Pharmaceutical companies established in 1815