Microtubule-associated serine/threonine-protein kinase 2 is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

that in humans is encoded by the ''MAST2''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. The

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

encoded by this gene controls

TRAF6 TRAF6 is a TRAF human protein. Function The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF recep ...

and NF-kappaB activity.

Interactions

MAST2 has been shown to

interact Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex trai ...

with PCLKC.

Model organisms

Model organism A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...

s have been used in the study of MAST2 function. A conditional

knockout mouse A knockout mouse, or knock-out mouse, is a genetically modified mouse (''Mus musculus'') in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are importan ...

line called ''Mast2^{tm1a(KOMP)Wtsi}'' has been generated. Male and female animals underwent a standardized

phenotypic screen In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological prop ...

to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping {, class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" , , + ''Mast2'' knockout mouse phenotype , - ! Characteristic!! Phenotype , - , colspan=2; style="text-align: center;" , All data available at.{ , - , Insulin , , bgcolor="#488ED3", Normal , - , Homozygous viability at P14 , , bgcolor="#488ED3", Normal , - , Homozygous Fertility , , bgcolor="#488ED3", Normal , - , Body weight , , bgcolor="#488ED3", Normal , - , Neurological assessment , , bgcolor="#488ED3", Normal , - , Grip strength , , bgcolor="#488ED3", Normal , - ,

Dysmorphology Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology. The relate ...