Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
that in humans is encoded by the ''MAPK8''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is a member of the
MAP kinase and
JNK
c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and ar ...
family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as
proliferation,
differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
s, and thus mediates immediate-early
gene expression in response to cell stimuli. The activation of this kinase by
tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha-induced
apoptosis. This
kinase is also involved in UV radiation-induced apoptosis, which is thought to be related to the
cytochrome c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in
T cell
A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell r ...
proliferation, apoptosis and differentiation. Four
alternately spliced transcript variants encoding distinct
isoform
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. While many perform the same or similar biological roles, some iso ...
s have been reported. MAPK8 contains multiple amino acid sites that are phosphorylated and ubiquitinated.
Interactions
MAPK8 has been shown to
interact with:
*
Activating transcription factor 2,
*
C-jun,
DUSP10
Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the ''DUSP10'' gene.
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine ...
,DUSP22
Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the ''DUSP22'' gene.
Interactions
DUSP22 has been shown to interact with MAPK1 and MAPK8
Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous e ...
,GSTP1
Glutathione S-transferase P is an enzyme that in humans is encoded by the ''GSTP1'' gene.
Function
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydr ...
,IRS1
Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the ''IRS-1'' gene. It is a 131 kDa protein with amino acid sequence of 1242 residues. It contains a single pleckstrin homology (PH) domain at the N-te ...
,ITCH
Itch (also known as pruritus) is a sensation that causes the desire or reflex to scratch. Itch has resisted many attempts to be classified as any one type of sensory experience. Itch has many similarities to pain, and while both are unpleasant ...
, [
* ]MAPK8IP1
C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the ''MAPK8IP1'' gene.
The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein ...
,MAPK8IP3
C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the ''MAPK8IP3'' gene.
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction ...
,Myc
''Myc'' is a family of regulator genes and proto-oncogenes that code for transcription factors. The ''Myc'' family consists of three related human genes: ''c-myc'' (MYC), ''l-myc'' ( MYCL), and ''n-myc'' (MYCN). ''c-myc'' (also sometimes refe ...
,REL Rel or REL may mean:
__NOTOC__ Science and technology
* REL, a human gene
* the rel descriptor of stereochemistry, see Relative configuration
*REL (''Rassemblement Européen pour la Liberté''), European Rally for Liberty, a defunct French far-ri ...
,SH3BP5
SH3 domain-binding protein 5 is a protein that in humans is encoded by the ''SH3BP5'' gene.
Interactions
SH3BP5 has been shown to interact with Bruton's tyrosine kinase and MAPK8
Mitogen-activated protein kinase 8 (also known as JNK1) is a ubi ...
,
References
Further reading
*
*
*
External links
MAP Kinase Resource
.
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