Mitogen-activated protein kinase 11 is an
enzyme that in humans is encoded by the ''MAPK11''
gene.
Function
The protein encoded by this gene is a member of the
MAP kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses ...
family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as Cell proliferation, proliferation, Cellular differentiation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 mitogen-activated protein kinases, p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by Mitogen-activated protein kinase kinase, MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor Activating transcription factor 2, ATF2/CREB2 has been shown to be a substrate of this kinase.
Interactions
MAPK11 has been shown to Protein-protein interaction, interact with HDAC3
and Promyelocytic leukemia protein.
See also
* p38 mitogen-activated protein kinases
References
External links
MAP Kinase Resource .
Further reading
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EC 2.7.11
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