Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''LRP4''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
LRP-4 is a member of the
Lipoprotein receptor-related protein
Lipoprotein receptor-related proteins, low density lipoprotein receptor-related proteins (HGNC) or prolow-density lipoprotein receptor-related protein (UniProt), abbreviated LRP, are a group of proteins.
They include:
* LRP1
*LRP1B
* LRP2 (megali ...
family and may be a regulator of
Wnt signaling
The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling ...
.
Clinical significance
Mutations in this gene are associated with
Cenani Lenz syndactylism.
Autoantibodies against LRP4 have been connected to a small fraction of
myasthenia gravis cases.
References
Further reading
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