LY-235959 is a competitive antagonist at the NMDA receptor. It has analgesic and

neuroprotective Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...

effects and causes

hypothermia Hypothermia is defined as a body core temperature below in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe ...

in animal models, as well as reducing the development of tolerance to morphine and altering the reinforcing effects of cocaine.

References

{{Ionotropic glutamate receptor modulators NMDA receptor antagonists Phosphonic acids Decahydroisoquinolines