LSD-Pip is a compound from the
ergoline
Ergoline is a chemical compound whose structural skeleton is contained in a variety of alkaloids, referred to as ergoline derivatives or ergoline alkaloids. Ergoline alkaloids, one being ergine, were initially characterized in ergot. Some of thes ...
family, related to
LSD
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
but with the ''N,N''-diethyl substitution replaced by a
piperidine
Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor de ...
group. It is more potent than the corresponding pyrrolidine and morpholine analogues (
LPD-824 and
LSM-775
''N''-Morpholinyllysergamide (LSM-775) is a derivative of ergine. It is less potent than LSD but is reported to have some LSD-like effects at doses ranging from 75 to 700 micrograms and a shorter duration. There are fewer signs of cardiovascular ...
respectively), but is still several times less potent than LSD as a
5-HT2A agonist.
Early studies suggested this compound to be inactive as a
psychedelic in humans,
though this does not seem to have been confirmed by any more recent work.
See also
*
Lysergic acid 2-butyl amide
Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue of LSD originally developed by Richard Pioch at Eli Lilly in the 1950s, but mostly publicised through research conducted by the team led by David E. Nichols at Purdue Universit ...
*
Lysergic acid 2,4-dimethylazetidide
Lysergic acid 2,4-dimethylazetidide (LA-SS-Az, LSZ) is an analog of LSD developed by the team led by David E. Nichols at Purdue University. It was developed as a rigid analog of LSD with the diethylamide group constrained into an azetidine ri ...
References
Lysergamides
Serotonin receptor agonists
1-Piperidinyl compounds
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