LP-44 is a drug which acts as a potent and selective

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ag ...

at the 5HT₇

serotonin receptor 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory ne ...

. While LP-44 is less selective than the related compound

LP-12 LP-12 is a drug which acts as a potent agonist at the 5HT7 serotonin receptor, with very high selectivity over other tested receptor subtypes such as the serotonin 5-HT1A and 5-HT2A, and the dopamine D2 receptor. It has been used to research the ...

, it has been more widely used in research and has been used to show the complex role of 5-HT₇ receptors in several aspects of brain function, including regulation of the sleep-wake cycle and roles in stress, learning and memory.

References

{{Piperazines 5-HT7 agonists 1-Aminotetralins Phenylpiperazines

See also

References