LIM homeobox transcription factor 1-beta, also known as LMX1B, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
which in humans is encoded by the ''LMX1B''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
LMX1B is a
LIM homeobox transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The f ...
which plays a central role in
dorso-ventral patterning of the vertebrate limb.
Clinical significance
Loss-of-function mutations in the ''LMX1B'' gene are associated with
Nail-patella syndrome.
References
Further reading
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External links
GeneReviews/NIH/NCBI/UW entry on Nail-Patella Syndrome*
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