L-694247 is a somewhat selective 5-HT_1D

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ag ...

, with a 10-fold greater

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for the 5-HT_1B receptor, and 25-fold greater affinity for the 5-HT_1A receptor. When L-694247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a 5-HT_1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.

References

Serotonin receptor agonists Sulfonamides Tryptamines Oxadiazoles 5-HT1D agonists {{nervous-system-drug-stub