The keratinocyte growth factor (KGF), also known as

FGF7 Keratinocyte growth factor is a protein that in humans is encoded by the ''FGF7'' gene. Function The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell surv ...

, is a

growth factor A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. Usually it is a secreted protein or a steroid hormone. Growth factors are important for regul ...

present in the

epithelialization Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. In undamaged skin, the epidermis (surface, epithelial layer) and dermis (deeper, connective layer) form a protective barrier agains ...

-phase of

wound healing Wound healing refers to a living organism's replacement of destroyed or damaged tissue by newly produced tissue. In undamaged skin, the epidermis (surface, epithelial layer) and dermis (deeper, connective layer) form a protective barrier again ...

. In this phase,

keratinocytes Keratinocytes are the primary type of cell found in the epidermis, the outermost layer of the skin. In humans, they constitute 90% of epidermal skin cells. Basal cells in the basal layer (''stratum basale'') of the skin are sometimes referre ...

are covering the wound, forming the epithelium. KGF is a small signaling molecule that binds to

fibroblast growth factor receptor 2b Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the ''FGFR2'' gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor. The protein ...

(FGFR2b). For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin. There are 23 known FGFs, and 4

FGF receptor FGF may refer to: * , the Football Federation of Rio Grande do Sul, Brazil * , the Football Federation of Goiás, Brazil * Fibroblast growth factor * Galician Football Federation (Spanish: '), in Spain * Guinean Football Federation The Guinean Fo ...

s. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.

FGF10 Fibroblast growth factor 10 is a protein that in humans is encoded by the ''FGF10'' gene. Function The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell s ...

is also known as "keratinocyte growth factor 2".FGF10 >

References

External links

FGF 2-FGFR 1c-Heparin (2:2:2) Complex
Growth factors {{protein-stub

See also

References

External links