Sir Joseph Barcroft (26 July 1872 – 21 March 1947) was a British

physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemica ...

best known for his studies of the oxygenation of

blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the cir ...

Life

Born in

Newry Newry (; ) is a City status in Ireland, city in Northern Ireland, divided by the Newry River, Clanrye river in counties County Armagh, Armagh and County Down, Down, from Belfast and from Dublin. It had a population of 26,967 in 2011. Newry ...

County Down County Down () is one of the six counties of Northern Ireland, one of the nine counties of Ulster and one of the traditional thirty-two counties of Ireland. It covers an area of and has a population of 531,665. It borders County Antrim to th ...

into a

Quaker Quakers are people who belong to a historically Protestant Christian set of denominations known formally as the Religious Society of Friends. Members of these movements ("theFriends") are generally united by a belief in each human's abili ...

family, he was the son of Henry Barcroft DL and Anna Richardson Malcomson of ''The Glen'', Newry – a property purchased for his parents by his mother's uncle,

John Grubb Richardson John Grubb Richardson (13 November 1813 – 1891) was an Irish linen merchant, industrialist and philanthropist who founded the model village of Bessbrook near Newry in 1845, in what is now Northern Ireland. Five years later he founded a major ...

and adjoining his own estate in

Bessbrook Bessbrook is a village in County Armagh, Northern Ireland. It lies about three miles (5 km) northwest of Newry and near the Newry bypass on the main A1 Belfast-Dublin road and Belfast-Dublin railway line. Today the village of Bessbrook str ...

. He was initially educated at

Bootham School Bootham School is an independent Quaker boarding school, on Bootham in the city of York in England. It accepts boys and girls ages 3–19, and had an enrolment of 605 pupils in 2016. It is one of seven Quaker schools in England. The schoo ...

York York is a cathedral city with Roman origins, sited at the confluence of the rivers Ouse and Foss in North Yorkshire, England. It is the historic county town of Yorkshire. The city has many historic buildings and other structures, such as a ...

and later at

The Leys School The Leys School is a co-educational independent school in Cambridge, England. It is a day and boarding school for about 574 pupils between the ages of eleven and eighteen, and a member of the Headmasters' and Headmistresses' Conference. Histo ...

, Cambridge. He married Mary Agnetta Ball, daughter of Sir Robert S. Ball, in 1903. He received his degree in Medicine and Science in 1896 from

Cambridge University , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

, and immediately began his studies of

haemoglobin Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocyte ...

. In May 1910 he was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemati ...

and would be awarded their

Royal Medal The Royal Medal, also known as The Queen's Medal and The King's Medal (depending on the gender of the monarch at the time of the award), is a silver-gilt medal, of which three are awarded each year by the Royal Society, two for "the most important ...

in 1922 and their

Copley medal The Copley Medal is an award given by the Royal Society, for "outstanding achievements in research in any branch of science". It alternates between the physical sciences or mathematics and the biological sciences. Given every year, the medal is t ...

in 1943. He would also deliver their

Croonian Lecture The Croonian Medal and Lecture is a prestigious award, a medal, and lecture given at the invitation of the Royal Society and the Royal College of Physicians. Among the papers of William Croone at his death in 1684, was a plan to endow a single ...

in 1935. In both the

First World War World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was List of wars and anthropogenic disasters by death toll, one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, ...

and

Second World War World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposi ...

he had the prestigious role of Chief Physiologist at the Gas Warfare Centre at Porton Down near

Salisbury Salisbury ( ) is a cathedral city in Wiltshire, England with a population of 41,820, at the confluence of the rivers Avon, Nadder and Bourne. The city is approximately from Southampton and from Bath. Salisbury is in the southeast of ...

. In 1936 he was nominated, unsuccessfully, by Professor

Arthur Dighton Stammers Arthur is a common male given name of Brythonic origin. Its popularity derives from it being the name of the legendary hero King Arthur. The etymology is disputed. It may derive from the Celtic ''Artos'' meaning “Bear”. Another theory, more w ...

, Professor of Physiology in the

University of the Witwatersrand The University of the Witwatersrand, Johannesburg (), is a multi-campus South African public research university situated in the northern areas of central Johannesburg. It is more commonly known as Wits University or Wits ( or ). The university ...

, for the

Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...

in Physiology or Medicine, for his work on the respiratory function of the blood and the functions of the spleen. In the course of his research, he did not hesitate to use himself as a test subject. For example, during the

, when he was called to Royal Engineers Experimental Station (near

) to carry out experiments on

asphyxia Asphyxia or asphyxiation is a condition of deficient supply of oxygen to the body which arises from abnormal breathing. Asphyxia causes generalized hypoxia, which affects primarily the tissues and organs. There are many circumstances that can ...

ting gas, he exposed himself to an atmosphere of poisonous

hydrogen cyanide Hydrogen cyanide, sometimes called prussic acid, is a chemical compound with the formula HCN and structure . It is a colorless, extremely poisonous, and flammable liquid that boils slightly above room temperature, at . HCN is produced on a ...

. On another occasion he remained for seven days in a glass chamber in order to calculate the minimum quantity of oxygen required for the survival of the human organism, and another time he exposed himself to such a low temperature that he collapsed into unconsciousness. He also studied the physiology of oxygenation at extreme altitudes, and for this purpose he organized expeditions to the peak of

Tenerife Tenerife (; ; formerly spelled ''Teneriffe'') is the largest and most populous island of the Canary Islands. It is home to 43% of the total population of the Archipelago, archipelago. With a land area of and a population of 978,100 inhabitant ...

(1910), to

Monte Rosa : , other_name = Monte Rosa massif , translation = Mount Rose , photo = Dufourspitze (Monte Rosa) and Monte Rosa Glacier as seen from Gornergrat, Wallis, Switzerland, 2012 August.jpg , photo_caption = Central Mon ...

(1911), and to the Peruvian

Andes The Andes, Andes Mountains or Andean Mountains (; ) are the longest continental mountain range in the world, forming a continuous highland along the western edge of South America. The range is long, wide (widest between 18°S – 20°S ...

(1922). Between 1902 and 1905 he was a Governor of

Leighton Park School Leighton Park School is a co-educational independent school for both day and boarding pupils in Reading in South East England. The school's ethos is closely tied to the Quaker values, having been founded as a Quaker School in 1890. The school's ...

, the Quaker School in Reading. From 1925 to 1937 he held the chair of physiology at Cambridge. His final research, begun in 1933, concerned

fetal A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal develo ...

respiration Respiration may refer to: Biology * Cellular respiration, the process in which nutrients are converted into useful energy in a cell ** Anaerobic respiration, cellular respiration without oxygen ** Maintenance respiration, the amount of cellul ...

. He was knighted in 1935. He was elected a Foreign Honorary Member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

in 1938. During the first years of the

he was again summoned to Porton Down to consult on

chemical weapon A chemical weapon (CW) is a specialized munition that uses chemicals formulated to inflict death or harm on humans. According to the Organisation for the Prohibition of Chemical Weapons (OPCW), this can be any chemical compound intended as a ...

s. He died in

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

in 1947.

Publications

*''The Respiratory Function of the Blood'' (1914) *''Features in the Architecture of the Physiological Function'' (1934)

Life

Publications

References

Further reading