In 1981, Garreau published The Nine Nations of North America. In 1991, he published Edge City: Life on the New Frontier. In 2005, he published Radical Evolution: The Promise and Peril of Enhancing Our Minds, Our Bodies—and What It Means to Be Human.
He has served as a fellow at Cambridge University, a Bernard L. Schwartz Fellow at New America Foundation, the University of California at Berkeley and George Mason University. Previously, he was a reporter and editor at The Washington Post.