JWH-424 is a drug from the

naphthoylindole Naphthoylindoles are a class of synthetic cannabinoids. See also * Structural scheduling of synthetic cannabinoids References {{reflist ...

family, which acts as a

cannabinoid Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...

agonist at both the CB₁ and CB₂

receptors Receptor may refer to: *Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ...

, but with moderate selectivity for CB₂, having a K_i of 5.44nM at CB₂ vs 20.9 nM at CB₁. The heavier 8- iodo analogue is even more CB₂ selective, with its 2-methyl derivative having 40 times selectivity for CB₂. However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall. In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-424 are

Schedule I Controlled Substance This is the list of Schedule I drugs as defined by the United States Controlled Substances Act. 21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pla ...

References

Naphthoylindoles JWH cannabinoids Bromoarenes Designer drugs CB1 receptor agonists {{cannabinoid-stub