JWH-359 is a dibenzopyran "classical" cannabinoid drug, which is a potent and selective CB₂ receptor agonist, with a K_i of 13.0 nM and selectivity of around 220 times for CB₂ over CB₁ receptors. It is related to other dibenzopyran CB₂ agonists such as JWH-133 and L-759,656 but with a

chiral Chirality is a property of asymmetry important in several branches of science. The word ''chirality'' is derived from the Greek (''kheir''), "hand", a familiar chiral object. An object or a system is ''chiral'' if it is distinguishable from i ...

side chain which has made it useful for mapping the shape of the CB₂ binding site. It was discovered by, and named after, John W. Huffman.

References

JWH cannabinoids Benzochromenes Phenol ethers Methoxy compounds {{cannabinoid-stub