JWH-149 is a synthetic
cannabimimetic that was discovered by
John W. Huffman. It is the ''N''-pentyl analog of
JWH-148. It is a potent but only moderately selective ligand for the
CB2 receptor, with a binding affinity of ''K''
i = 0.73 ± 0.03 nM at this subtype, and more than six times selectivity over the CB
1 subtype.
In the United States, all CB
1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-149 are
Schedule I Controlled Substance
This is the list of Schedule I drugs as defined by the United States Controlled Substances Act. 21 CFRbr>1308.11(CSA Sched I) with changes through (Oct 18, 2012). Retrieved September 6, 2013. The following findings are required for drugs to be pla ...
s.
See also
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JWH-120
*
JWH-122
JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is a methylated analogue of JWH-018. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2.
In January 2015, over 40 people were reportedly sickened after eating a holid ...
*
JWH-148
*
JWH-193
JWH-193 is a drug from the aminoalkylindole and naphthoylindole families which acts as a cannabinoid receptor agonist. It was invented by the pharmaceutical company Sanofi-Winthrop in the early 1990s. JWH-193 has a binding affinity at the CB1 r ...
*
JWH-210
JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substi ...
*
JWH-398
JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It has mild selectivity for CB1 with a Ki of 2.3 nM and 2.8 nM at CB2. This synthetic chemical comp ...
References
JWH cannabinoids
Naphthoylindoles
Designer drugs
CB1 receptor agonists
CB2 receptor agonists
{{cannabinoid-stub